Pubblicazioni scientifiche
Pubblicazioni scientifiche del Registro Tumori Veneto.
Colonoscopy related adverse events and mortality in an Italian organized colorectal cancer screening program
Benazzato L, Zorzi M, Antonelli G, Guzzinati S, Hassan C, Fantin A. [published online ahead of print, 2020 Jul 28]. Endoscopy. 2020;10.1055/a-1228-9225. doi:10.1055/a-1228-9225 Abstract Background and Aims Post-colonoscopy adverse events (AE) are a key quality indicator in population-based colorectal cancer screening programs, affecting safety and costs. Aim of this study was to assess colonoscopy-related AE and mortality in a screening setting. Methods We retrieved data from a cohort of patients undergoing colonoscopy within a screening program (Faecal Immunochemical Test every 2 years, 50...
SARS-CoV-2 infection in the Italian Veneto region: adverse outcomes in patients with cancer
Rugge M., Zorzi M. & Guzzinati S. Nat Cancer (2020). https://doi.org/10.1038/s43018-020-0104-9 Abstract In 84,246 consecutive Italians tested for SARS-CoV-2, we examined the prevalence of cancer and clinical outcomes of viral infection. Overall, 5.7% (4,789/84,246) had previously been diagnosed with cancer and, among the SARS-CoV-2-positive (CV2+ve) patients, 7.8% had a cancer diagnosis (723/9,275). Prevalence of cancer was not associated with risk of infection (odds ratio of 0.97; 95% confidence interval of 0.89–1.06). The proportion of CV2+ve people hospitalized was higher among...
Patterns of Care and Cost Profiles of Women With Breast Cancer in Italy: EPICOST Study Based on Real World Data
Francisci S, Guzzinati S, Capodaglio G, Pierannunzio D, Mallone S, Tavilla A, Lopez T, Busco S, Mazzucco W, Angiolini C, Zorzi M, Serraino D, Barchielli A, Fusco M, Stracci F, Bianconi F, Rugge M, Iacovacci S, Russo AG, Cusimano R, Gigli A. Eur J Health Econ. 2020 May 12. doi: 10.1007/s10198-020-01190-z. Online ahead of print. Abstract Objectives: To estimate total direct health care costs associated to diagnosis and treatment of women with breast cancer in Italy, and to investigate their distribution by service type according to the disease pathway and patient characteristics. Methods:...
Interval colorectal cancers after negative faecal immunochemical test in a 13-year screening programme
Zorzi M, Hassan C, Senore C, Capodaglio G, Turrin A, Narne E, Mussato A, Rizzato S, Chinellato E, Zamberlan S, Repici A, Rugge M. J Med Screen. 2020 May 11:969141320918613. doi: 10.1177/0969141320918613. Online ahead of print. Abstract Objective: To assess faecal immunochemical test sensitivity for cancer in a very large population-based cohort followed up for six rounds with biennial faecal immunochemical test repetition. Methods: This study is based on interval colorectal cancers diagnosed in a cohort of subjects aged 50-69 undergoing repeated faecal immunochemical test screening (six...
Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (n=4532)
Montopoli M, Zumerle S, Vettor R, Rugge M, Zorzi M, Catapano CV, Carbone GM, Cavalli A, Pagano F, Ragazzi E, Prayer-Galetti T, Alimonti A. Ann Oncol. 2020 May 4:S0923-7534(20)39797-0. doi: 10.1016/j.annonc.2020.04.479. Online ahead of print. Abstract Background: Cell entry of SARS-CoV-2 depends on binding of the viral spike (S) proteins to ACE2 and on S protein priming by TMPRSS2. Inhibition of TMPRSS2 may work to block or decrease the severity of SARS-CoV-2 infections. Intriguingly, TMPRSS2 is an androgen-regulated gene that is upregulated in prostate cancer where it supports tumor...
Colonoscopy later than 270 days in a fecal immunochemical test-based population screening program is associated with higher prevalence of colorectal cancer
Zorzi M, Hassan C, Capodaglio G, Baracco M, Antonelli G, Bovo E, Rugge M. Endoscopy. 2020 Apr 30. doi: 10.1055/a-1159-0644. Online ahead of print. Abstract BACKGROUND : Colorectal cancer (CRC) screening programs based on fecal immunochemical testing (FIT) generate substantial pressure on colonoscopy capacity in Europe. Thus, a relevant proportion of FIT-positive patients undergo colonoscopy after the recommended 30-day interval, which may be associated with an excess CRC risk. METHODS : In a cohort of 50-69-year-old patients undergoing biennial rounds of FIT (OC-Hemodia latex agglutination...
A Therapeutic and Diagnostic Multidisciplinary Pathway for Merkel Cell Carcinoma Patients
Rastrelli M, Del Fiore P, Buja A, Vecchiato A, Rossi CR, Chiarion Sileni V, Tropea S, Russano F, Zorzi M, Spina R, Cappellesso R, Mazzarotto R, Cavallin F, Bassetto F, Bezzon E, Ferrazzi B, Alaibac M, Mocellin S. Front Oncol. 2020 Apr 15;10:529. doi: 10.3389/fonc.2020.00529. eCollection 2020. Abstract Merkel Cell Carcinoma (MCC) is a highly aggressive neuroendocrine neoplasm of the skin. Due to its rarity, the management of MCC is not standardized across centers. In this article, we present the experience of the Veneto region in the North-East of Italy, where a committee of skin cancer...
Adolescent and Young Adult Cancer Survivors: Design and Characteristics of the First Nationwide Population-Based Cohort in Italy
Bernasconi A, Barigelletti G, Tittarelli A, Botta L, Gatta G, Tagliabue G, Contiero P, Guzzinati S, Andreano A, Manneschi G, Falcini F, Castaing M, Filiberti RA, Gasparotti C, Cirilli C, Mazzucco W, Mangone L, Iacovacci S, Vitale MF, Stracci F, Piffer S, Tumino R, Carone S, Sampietro G, Melcarne A, Ballotari P, Boschetti L, Pisani S, D'Oro LC, Cuccaro F, D'Argenzio A, D'Orsi G, Fanetti AC, Ardizzone A, Candela G, Savoia F, Pascucci C, Castelli M, Storchi C, Trama A. J Adolesc Young Adult Oncol. 2020 Apr 13. doi: 10.1089/jayao.2019.0170. [Epub ahead of print] Abstract Purpose: Adolescent...
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